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61.
Asghar Zeeshan Ali Nasir Waqas Muhammad Nazeer Mubbashar Khan Waqar Azeem 《Biomechanics and modeling in mechanobiology》2020,19(6):2271-2284
Biomechanics and Modeling in Mechanobiology - Every group of microorganism utilizes a diverse mechanical strategy to propel through complex environments. These swimming problems deal with the... 相似文献
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Laura Pastorino Elena Dellacasa Mohamed R. Noor Tewfik Soulimane Paolo Bianchini Francesca D'Autilia Alexei Antipov Alberto Diaspro Syed A. M. Tofail Carmelina Ruggiero 《PloS one》2014,9(11)
Cell-sized polyelectrolyte capsules functionalized with a redox-driven proton pump protein were assembled for the first time. The interaction of polyelectrolyte microcapsules, fabricated by electrostatic layer-by-layer assembly, with cytochrome c oxidase molecules was investigated. We found that the cytochrome c oxidase retained its functionality, that the functionalized microcapsules interacting with cytochrome c oxidase were permeable and that the permeability characteristics of the microcapsule shell depend on the shell components. This work provides a significant input towards the fabrication of an integrated device made of biological components and based on specific biomolecular functions and properties. 相似文献
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A key question in the field of RNA regulation is how some exosome substrates, such as spliceosomal snRNAs and telomerase RNA, evade degradation and are processed into stable, functional RNA molecules. Typical feature of these non-coding RNAs is presence of the Sm complex at the 3′end of the mature RNA molecule. Here, we report that in Saccharomyces cerevisiae presence of intact Sm binding site is required for the exosome-mediated processing of telomerase RNA from a polyadenylated precursor into its mature form and is essential for its function in elongating telomeres. Additionally, we demonstrate that the same pathway is involved in the maturation of snRNAs. Furthermore, the insertion of an Sm binding site into an unstable RNA that is normally completely destroyed by the exosome, leads to its partial stabilization. We also show that telomerase RNA accumulates in Schizosaccharomyces pombe exosome mutants, suggesting a conserved role for the exosome in processing and degradation of telomerase RNA. In summary, our data provide important mechanistic insight into the regulation of exosome dependent RNA processing as well as telomerase RNA biogenesis. 相似文献
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Calum Brown Dave Murray-Rust Jasper van Vliet Shah Jamal Alam Peter H. Verburg Mark D. Rounsevell 《PloS one》2014,9(12)
The globalisation of trade affects land use, food production and environments around the world. In principle, globalisation can maximise productivity and efficiency if competition prompts specialisation on the basis of productive capacity. In reality, however, such specialisation is often constrained by practical or political barriers, including those intended to ensure national or regional food security. These are likely to produce globally sub-optimal distributions of land uses. Both outcomes are subject to the responses of individual land managers to economic and environmental stimuli, and these responses are known to be variable and often (economically) irrational. We investigate the consequences of stylised food security policies and globalisation of agricultural markets on land use patterns under a variety of modelled forms of land manager behaviour, including variation in production levels, tenacity, land use intensity and multi-functionality. We find that a system entirely dedicated to regional food security is inferior to an entirely globalised system in terms of overall production levels, but that several forms of behaviour limit the difference between the two, and that variations in land use intensity and functionality can substantially increase the provision of food and other ecosystem services in both cases. We also find emergent behaviour that results in the abandonment of productive land, the slowing of rates of land use change and the fragmentation or, conversely, concentration of land uses following changes in demand levels. 相似文献
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Leonid Beigelman Alexander Karpeisky Nassim Usman 《Nucleosides, nucleotides & nucleic acids》2013,32(3-5):895-899
Abstract The synthesis of phosphoramidites of 6-modified pyrimidine ribonucleosides and their incorporation into hammerhead ribozymes and influence on nuclease stability and catalytic activity is described. 相似文献
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Perveen Sumera Khan Tehmina Ahsan Shaheen Humaira Naz Rabia Hyder Muhammad Zeeshan Ijaz Bushra Naqvi S. M. Saqlan Yasmin Tayyaba 《In vitro cellular & developmental biology. Plant》2021,57(6):907-922
In Vitro Cellular & Developmental Biology - Plant - The OsRGLP1 gene was overexpressed under the control of CaMV 35S promoter in tomato (Solanum lycopersicum L.) plants using... 相似文献
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In this paper, a fractional complex transform (FCT) is used to convert the given fractional partial differential equations (FPDEs) into corresponding partial differential equations (PDEs) and subsequently Reduced Differential Transform Method (RDTM) is applied on the transformed system of linear and nonlinear time-fractional PDEs. The results so obtained are re-stated by making use of inverse transformation which yields it in terms of original variables. It is observed that the proposed algorithm is highly efficient and appropriate for fractional PDEs and hence can be extended to other complex problems of diversified nonlinear nature. 相似文献